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1984 1
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1989 1
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2006 1
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2011 3
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2017 2
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2019 4
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2022 3
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39 results

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Page 1
Preclinical activity and determinants of response of the GPRC5DxCD3 bispecific antibody talquetamab in multiple myeloma.
Verkleij CPM, Broekmans MEC, van Duin M, Frerichs KA, Kuiper R, de Jonge AV, Kaiser M, Morgan G, Axel A, Boominathan R, Sendecki J, Wong A, Verona RI, Sonneveld P, Zweegman S, Adams HC, Mutis T, van de Donk NWCJ. Verkleij CPM, et al. Blood Adv. 2021 Apr 27;5(8):2196-2215. doi: 10.1182/bloodadvances.2020003805. Blood Adv. 2021. PMID: 33890981 Free PMC article.
Cell surface expression levels of GPRC5D, an orphan G protein-coupled receptor, are significantly higher on multiple myeloma (MM) cells, compared with normal plasma cells or other immune cells, which renders it a promising target for immunotherapeutic strategies. ...
Cell surface expression levels of GPRC5D, an orphan G protein-coupled receptor, are significantly higher on multiple myeloma (MM) cel …
Clinical exome sequencing: results from 2819 samples reflecting 1000 families.
Trujillano D, Bertoli-Avella AM, Kumar Kandaswamy K, Weiss ME, Köster J, Marais A, Paknia O, Schröder R, Garcia-Aznar JM, Werber M, Brandau O, Calvo Del Castillo M, Baldi C, Wessel K, Kishore S, Nahavandi N, Eyaid W, Al Rifai MT, Al-Rumayyan A, Al-Twaijri W, Alothaim A, Alhashem A, Al-Sannaa N, Al-Balwi M, Alfadhel M, Rolfs A, Abou Jamra R. Trujillano D, et al. Eur J Hum Genet. 2017 Feb;25(2):176-182. doi: 10.1038/ejhg.2016.146. Epub 2016 Nov 16. Eur J Hum Genet. 2017. PMID: 27848944 Free PMC article.
Coupling ammonia nitrogen adsorption and regeneration unit with a high-load anoxic/aerobic process to achieve rapid and efficient pollutants removal for wastewater treatment.
Qiang J, Zhou Z, Wang K, Qiu Z, Zhi H, Yuan Y, Zhang Y, Jiang Y, Zhao X, Wang Z, Wang Q. Qiang J, et al. Water Res. 2020 Mar 1;170:115280. doi: 10.1016/j.watres.2019.115280. Epub 2019 Nov 9. Water Res. 2020. PMID: 31759237
In this study, an ammonium nitrogen (NH(4)(+)-N) adsorption and regeneration (AAR) was constructed by a zeolite-packed column and NaClO-NaCl regeneration unit, and coupled with an anoxic/aerobic (AO) system to achieve efficient removal of carbon, nitrogen and phosph …
In this study, an ammonium nitrogen (NH(4)(+)-N) adsorption and regeneration (AAR) was constructed by a zeolite-packed column and NaC …
An Office-Initiated Multilevel Intervention for Tobacco Smoke Exposure: A Randomized Trial.
Collins BN, Lepore SJ, Winickoff JP, Nair US, Moughan B, Bryant-Stephens T, Davey A, Taylor D, Fleece D, Godfrey M. Collins BN, et al. Pediatrics. 2018 Jan;141(Suppl 1):S75-S86. doi: 10.1542/peds.2017-1026K. Pediatrics. 2018. PMID: 29292308 Free PMC article. Clinical Trial.
We hypothesized that a pragmatic, multilevel treatment model including AAR coupled with individualized, telephone-based behavioral counseling promoting child TSE reduction would demonstrate greater child TSE reduction than would standard AAR. ...Participants …
We hypothesized that a pragmatic, multilevel treatment model including AAR coupled with individualized, telephone-based behavi …
Moonlighting characteristics of G protein-coupled receptors: focus on receptor heteromers and relevance for neurodegeneration.
Borroto-Escuela DO, Tarakanov AO, Guidolin D, Ciruela F, Agnati LF, Fuxe K. Borroto-Escuela DO, et al. IUBMB Life. 2011 Jul;63(7):463-72. doi: 10.1002/iub.473. IUBMB Life. 2011. PMID: 21698749 Free article. Review.
It is proposed that the moonlighting concept can be applied to G protein coupled receptors (GPCRs) as, obviously, they can carry out different types of functions. ...A "guide-and-clasp" manner of receptor-receptor interactions has been proposed where the "adhesive guides" …
It is proposed that the moonlighting concept can be applied to G protein coupled receptors (GPCRs) as, obviously, they can carry out …
Engineering an acetoacetyl-CoA reductase from Cupriavidus necator toward NADH preference under physiological conditions.
Olavarria K, Pijman YO, Cabrera R, van Loosdrecht MCM, Wahl SA. Olavarria K, et al. Sci Rep. 2022 Mar 8;12(1):3757. doi: 10.1038/s41598-022-07663-w. Sci Rep. 2022. PMID: 35260659 Free PMC article.
The coupling of PHB generation with NADH reoxidation is required to generate PHB as a fermentation product. ...One way to obtain such a reductase is by engineering the cofactor preference of the acetoacetyl-CoA reductase encoded by the phaB1 gene from Cupriavidus necator ( …
The coupling of PHB generation with NADH reoxidation is required to generate PHB as a fermentation product. ...One way to obtain such …
Liposomal tetrahydrobiopterin preserves eNOS coupling in the post-ischemic heart conferring in vivo cardioprotection.
Xie L, Talukder MA, Sun J, Varadharaj S, Zweier JL. Xie L, et al. J Mol Cell Cardiol. 2015 Sep;86:14-22. doi: 10.1016/j.yjmcc.2015.06.015. Epub 2015 Jun 25. J Mol Cell Cardiol. 2015. PMID: 26116866 Free PMC article.
With liposomal BH4 treatment, BH4 levels were identical in the AAR and NI area during ischemia and/or early reperfusion, and were significantly higher than with vehicle. BH4 pre-treatment preserved eNOS Ser1177 phosphorylation and NOS activity in the AAR, and signif …
With liposomal BH4 treatment, BH4 levels were identical in the AAR and NI area during ischemia and/or early reperfusion, and were sig …
A meta-analysis of the effectiveness of the after-action review (or debrief) and factors that influence its effectiveness.
Keiser NL, Arthur W. Keiser NL, et al. J Appl Psychol. 2021 Jul;106(7):1007-1032. doi: 10.1037/apl0000821. Epub 2020 Aug 27. J Appl Psychol. 2021. PMID: 32852990
The effects of the other training characteristics were often interactive. Most notably, the facilitation approach contributes to the effectiveness of the AAR in combination with the individual versus the team and the type of review media, with the most effective com …
The effects of the other training characteristics were often interactive. Most notably, the facilitation approach contributes to the …
Enzymatic diastereo- and enantioselective synthesis of α-alkyl-α,β-dihydroxyketones.
Giovannini PP, Fantin G, Massi A, Venturi V, Pedrini P. Giovannini PP, et al. Org Biomol Chem. 2011 Dec 7;9(23):8038-45. doi: 10.1039/c1ob05928a. Epub 2011 Oct 18. Org Biomol Chem. 2011. PMID: 22006343
An enzymatic strategy for the preparation of optically pure alpha-alkyl-alpha,beta-dihydroxyketones is reported. Homo- and cross-coupling reactions of alpha-diketones catalyzed by acetylacetoin synthase (AAS) produce a set of alpha-alkyl-alpha-hydroxy-beta-diketones (30-60 …
An enzymatic strategy for the preparation of optically pure alpha-alkyl-alpha,beta-dihydroxyketones is reported. Homo- and cross-coupling …
39 results